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Boehringer Acquires NASH Drug Under Pharmaxis Alliance

Phase I drug demonstrates oral bioavailability, target inhibition, safety and tolerability

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By: Kristin Brooks

Managing Editor, Contract Pharma

Boehringer Ingelheim has exercised the option under its Pharmaxis alliance to acquire the investigational drug PXS4728A for the treatment of the liver-related condition NASH. PXS4728A is a Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein-1 (SSAO/VAP-1) Inhibitor that works as an anti-inflammatory, and in Phase I studies, demonstrated oral bioavailability, long-lasting target inhibition and good safety and tolerability.     Pharmaxis will receive $39 million upfront and is eligible...

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